团队带头人窦效伟 教授，博导，国家级创新人才，泰山产业领军人才，团队聚焦细胞与基因治疗、海洋生物医药开发及抗菌肽研究三大领域。团队牵头成立现代生物医药技术研究院，由团队带头人窦效伟教授担任研究院院长，诺奖获得者兰迪・谢克曼教授担任研究院名誉院长。目前团队拥有教授2名，副教授1名，特聘副教授博士后1名，博士1名及硕士生30余人，具备跨学科协同能力，致力于基础研究与转化应用的深度融合。
团队研究领域和方向
（一）外泌体与细胞治疗平台
以外泌体与细胞治疗为核心，我们聚焦干细胞及其外泌体的医药化改造研究。通过基因工程技术对功能性分子进行特异性设计与定向修饰，并整合材料科学与生物工程手段，构建具备靶向响应能力的智能化生物递送平台。该平台可实现治疗分子的时空可控释放，显著提高治疗精准度，降低脱靶效应与副作用风险。在此基础上，我们致力于实现两大核心目标：精准调节局部免疫微环境以纠正异常免疫反应，高效激活内源性组织再生机制以推动受损组织的结构与功能重建。该策略为神经退行性疾病、心肌损伤及慢性难愈合创面等退行性疾病提供了全新的治疗思路，我们将持续推动技术转化，为临床患者带来更安全、高效的细胞与外泌体治疗方案。
（二）mRNA技术与精准基因递送平台
我们致力于构建模块化、通用型的创新mRNA技术平台，涵盖抗原精准设计与新型LNP载体开发两大核心模块。该平台深度拓展mRNA在肿瘤疫苗及蛋白替代疗法中的应用潜力，旨在打造能够快速响应重大疾病挑战的体内蛋白质原位合成平台，为个性化治疗提供敏捷解决方案。与此同时，我们聚焦遗传性及代谢性疾病的根源，深耕新型病毒载体（AAV）与非病毒脂质纳米颗粒（LNP）的底层技术创新。通过系统优化递送效率、靶向特异性及基因表达的可控性，构建高效、持久的精准基因治疗递送系统，为临床根治性疗法提供核心支撑。
（三）合成生物学与海洋新药发现平台
积极响应国家海洋战略与“健康中国”需求，我们应用合成生物学技术构建高效的海洋生物活性分子筛选与评价平台，抗菌肽研究开发利用。聚焦海洋微生物资源，深度挖掘具有全新作用机制的先导化合物，致力于慢性病防治及新型抗感染药物的研发，为国民健康提供源头创新驱动，助力解决临床耐药性及难治性疾病等重大挑战。
团队成果
（1）团队带头人窦效伟教授的代表性文章发表在PNAS、Bio Psych等杂志，研究结果被NIH和哈佛大学通讯及国内外社会媒体专题通讯。
（2）团队科研成果卓著，团队负责人参与并管理美国国立卫生研究院（NIH）等机构重大科研项目3项，团队共计主持和参与国家级和省部级项目10余项。最新研究成果发表在elife等国际顶级期刊上，团队共发表SCI高水平论文70余篇，授权发明专利11项，鉴定科技成果2项。
现代生物医药团队致力于打造开放、合作、创新的学术平台，期待与您携手，共同推动生物医药科技进步！我们的愿景是成为基因与细胞治疗领域国际领先研究团队，为全球患者带来突破性的治疗方案！
联系邮箱：Dou_xiaowei@outlook.com
团队成员
团队在读研究生 (Graduate)
团队学术活动 (Academic Activities)
1. 2025.10.21 生物与医药国际论坛
2. 2026.7.10 “神经系统疾病研究与交叉学科融合”学术交留会
3. 2026.5.14 研究生毕业答辩
Modern Biomedicine Team
Team Introduction
Professor Xiaowei Dou, PhD supervisor, National Innovative Talent, and Taishan Industrial Leadership Talent of Shandong Province, leads the team. The team focuses on three major research areas: gene/cell therapy, marine biomedical development, and antimicrobial peptide research. The team has taken the lead in establishing the Institute of Modern Biomedicine and Biotechnology, with Professor Xiaowei Dou serving as the Dean of the Institute and Nobel Laureate Professor Randy W. Schekman serving as the Honorary Dean. The team currently consists of 2 professors, 1 associate professor, 1 specially appointed associate professor (postdoctoral), 1 PhD researcher, and over 30 master's students, possessing interdisciplinary collaborative capabilities and committed to the deep integration of fundamental research and translational applications.
Team Research Areas and Directions
(1) Precision gene therapy delivery systems: Focusing on the root causes of genetic and metabolic diseases, we are dedicated to underlying technological innovations in novel viral vectors (AAV) and non-viral lipid nanoparticles (LNP). By optimizing delivery efficiency, targeting specificity, and controllability of gene expression, we aim to build an efficient and durable gene therapy technology system, providing core support for clinical curative therapies.
(2) Engineered exosomes and cell therapy: Combining cutting-edge cell engineering technologies with the essence of Traditional Chinese Medicine theory, we focus on the directed modification of stem cells and their derived exosomes. By loading specific functional molecules, we aim to construct intelligent biological delivery platforms for precise immunomodulation and tissue regeneration, offering innovative solutions for degenerative diseases and injury repair.
(3) Innovative mRNA technology platform: We are developing a modular and versatile mRNA research and development system, covering precision antigen design and novel LNP carrier development, with the goal of expanding the application potential of mRNA in tumor vaccines and protein replacement therapies, ultimately establishing an in situ protein synthesis platform capable of rapidly responding to major disease challenges.
(4) Marine bioactive substances and new drug discovery: In response to the national marine strategy and the "Healthy China" initiative, we have established a high-efficiency platform for the screening and evaluation of marine bioactive molecules. Focusing on marine microbial resources, we aim to discover lead compounds with novel mechanisms of action, dedicated to the prevention and treatment of chronic diseases and the development of new anti-infective agents, providing a source of innovative drivers for national health.
Team Achievements
(1) Professor Xiaowei Dou, the team leader, has published representative papers in the Proceedings of the National Academy of Sciences (PNAS) and the Journal of Biological Chemistry (JBC). The PNAS editorial office, the National Institutes of Health (NIH), Harvard University, and various domestic and international media outlets have published special communications on the related research.
(2) The team has achieved remarkable research outcomes. The team leader has participated in and assisted in the management of 3 major research projects funded by the National Institutes of Health (NIH) and other institutions. Collectively, the team has led and participated in more than 10 national and provincial-level projects. The latest research findings have been published in eLife and other top-tier international journals. In total, the team has published over 70 high-quality SCI-indexed papers, been granted 11 invention patents, and achieved 2 technology evaluation certifications.
Team Members
Professor Xiaowei Dou, Team Leader; Professor Fang Li; Associate Professor Xia Wang; Postdoctoral Zexiu Qi
Team Academic Activities
The Modern Biomedicine Team has organized a series of important academic activities aimed at promoting cutting-edge research exchanges and fostering innovative talent. These include graduate thesis defenses and an academic symposium on "Research on Neurological Diseases and Interdisciplinary Integration." The symposium brought together experts and scholars from various disciplinary backgrounds, spanning from molecular mechanisms to clinical applications, and from biotechnology to artificial intelligence. The multidimensional interdisciplinary discussions provided new perspectives and approaches for research on neurological diseases.
Modern Biomedicine Team is committed to building an open, collaborative, and innovative academic platform. We look forward to joining hands with you to jointly advance scientific and technological progress in biomedicine! Our vision is to become a world-leading research team in the field of gene and cell therapy, bringing breakthrough treatment options to patients worldwide!
Email: Dou_xiaowei@outlook.com
