个人简介

李红燕，中国海洋大学药物化学博士。2020年05月加入青岛科技大学海洋科学与生物工程学院，主要从事海洋生物资源功能、稳态化及纳米递送相关研究。主持省部市级等项目8项，在《Carbohydrate Polymers》、《International Journal of Biological Macromolecules》等国际学术期刊发表SCI论文30余篇，申请发明专利9件，担任《Carbohydrate Polymers》、《International Journal of Biological Macromolecules》、《Process Biochemistry》、《Glycoconjugate Journal》等国际学术期刊审稿人。

主要研究方向：

1. 海洋来源多糖结构与生物活性研究

2. 海洋来源天然活性物质稳态化及纳米递送

3. 药食同源植物多糖结构、功能评价及开发利用

科研项目：

1. 青岛科技大学高层次人才启动经费，2020-09至2023-08，在研，主持

2. 国家自然科学基金项目，32072348，嗜盐菌代谢影响传统发酵虾酱特征风味形成的分子机制，2021-01至2024-12，在研，参与

3. 食品质量与安全北京实验室开放课题，FQS-202108，壳聚糖衍生物对扇贝中PSTs毒素的消减机制研究，2021-06至2022-05，在研，主持

4. 青岛宝创生物科技有限公司，海洋真菌胞外多糖研发技术，2020-04至2022-03，在研，主持

5. 中国博士后科学基金项目，2018M642706，海参皂苷靶向长效纳米脂质体的制备及抗乳腺癌活性研究，2018-06至2019-12，已结题，主持

6. 山东省人力资源和社会保障厅，博士后创新项目，肝靶向苦菜多糖的制备、结构及抗肝癌作用研究，2017-07至2018-12，已结题，主持

7. 河北省自然科学基金项目，B2015201069，板栗多糖资源开发的基础研究，2015-01至2016-12，已结题，主持

8. 河北省教育厅项目，QN2014131，以拓扑异构酶I为靶点的板栗多糖活性片段的筛选与结构表征，2014-01至2016-12，已结题，主持

9. 国家自然科学基金项目，41076086，礁膜抗凝血活性鼠李聚糖硫酸酯的可控降解与构效关系研究，2011-01至2013-12，已结题，参与

第一及通讯作者论文：

1. Li Hongyan, Xie Wancui, Sun Haihong, Cao Kewei, Yang, Xihong*, Effect of structural characterization of the fungal polysaccharides on their immunomodulatory activity, International Journal of Biological Macromolecules, 2020, 164: 3603-3610.

2. Li Hongyan*; Xie Wancui; Qiao Xing; Cui Huanhuan; Yang Xihong; Xue Changhu, Structural characterization of arabinogalactan extracted from Ixeris chinensis (Thunb.) Nakai and its immunomodulatory effect on RAW264.7 macrophages, International Journal of Biological Macromolecules, 2020, 143: 977-983.

3. Li Hongyan, Liu Dandan, Li Shenghui, Xue Changhu, Synthesis and cytotoxicity of selenium nanoparticles stabilized by α-D-glucan from Castanea mollissima Blume. International Journal of Biological Macromolecules, 2019, 129, 818-826.

4. Cui Huanhuan, Li Hongyan*, Wang Yingxing, Li Shenghui, Xue Changhu*, Structural characterization and biological activity of galactoglucan from Castanea mollissima Blume, Journal of Carbohydrate Chemistry, 2019, 38, 398-411.

5. Li Hongyan*, Cao Kewei, Cong Peixu, Liu Yanjun, Cui Huanhuan, Xue Changhu*, Structure characterization and antitumor activity of the extracellular polysaccharide from the marine fungus Hansfordia sinuosae. Carbohydrate Polymers, 2018, 190, 87-94.

6. Li Hongyan, Wang Yingxing, Wang Chao, Zhang Shaohan, Li Shenghui*, Zhou Guoqiang, Wang Shuxiang, Zhang Jinchao*, Extraction, selenylation modification and antitumor activity of the glucan from Castanea mollissima Blume. Glycoconjugate Journal, 2017, 34, 207-217.

7. Li Hongyan*, Yu He, Zhu Huajie*. Structure studies of the extracellular polysaccharide from Trichoderma sp. KK19L1 and its antitumor effect via cell cycle arrest and apoptosis, Applied Biochemistry and Biotechnology, 2017, 182:128-141.

8. Li Hongyan*, Liu Xin, Xu Yan, Wang Xiaoke, Zhu Huajie*, Structure and antitumor activity of the extracellular polysaccharides from Aspergillus aculeatus via apoptosis and cell cycle arrest. Glycoconjugate Journal, 2016, 33, 975-984.

9. Li Hongyan*, Gao Tong, Wang Jingchen, Tian Shasha, Yuan Xin，Zhu Huajie*, Structure identification and antitumor activity of the extracellular polysaccharide from Aspergillus terreus. Process Biochemistry, 2016, 51, 1714-1720.

10. Li Hongyan, Mao Wenjun*, Hou Yujiao, Gao Yan, Qi Xiaohui, Zhao Chunqi, Chen Yin, Chen Yanli, Li Na, Wang Chunyan, Preparation, structure and anticoagulant activity of a low molecular weight fraction produced by mild acid hydrolysis of the sulfated rhamnan from Monostroma latissimum. Bioresource Technology, 2012, 114, 414-418.

11. Li Hongyan, Mao Wenjun*, Chen Yin, Ren Sumei, Qi Xiaohui, Chen Yanli, Zhao Chunqi, Li Na, Wang Chunyan, Lin Cong, Yan Mengxia, Shan Jimiao, Sequence analysis of the sulfated rhamno -oligosaccharides derived from a sulfated rhamnan. Carbohydrate Polymers, 2012, 90:1299-1304.

12. Li Hongyan, Mao Wenjun*, Zhang Xiuli, Qi Xiaohui, Chen Yin, Chen Yanli, Xu Jian, Zhao Chunqi, Hou Yujiao, Yang Yupin, Li Na, Wang Chunyan, Structural characterization of an anticoagulant -active sulfated polysaccharide isolated from green alga Monostroma latissimum. Carbohydrate Polymers, 2011, 85, 394-400.

13. Mao Wenjun*, Li Hongyan, Li Yi, Zhang Huijuan, Qi Xiaohui, Sun Haihong, Chen Yin, Guo Shoudong, Chemical characteristic and anticoagulant activity of the sulfated polysaccharide isolated from Monostroma latissimum (Chlorophyta), International Journal of Biological Macromolecules, 2009, 44:70-74.

授权及申请专利：

1. 板栗种仁α-1,6-葡聚糖及其制备方法以及在抗肿瘤药物中的应用，李红燕，王应杏，张金超，王书香，李胜辉，周国强，刘丹丹，2017.8.25，中国，ZL201510333089.8

2. 一种可供注射给药的海参皂苷纳米脂质体及其制备方法，薛长湖，李红燕，崔欢欢，柯枭，徐杰，王玉明，李兆杰， 2021.7.23，中国，ZL201910203903.2

3. 一种天麻大分子线性直链葡聚糖及其制备方法和应用，李红燕，解万翠，杨锡洪，宋琳，车红霞，董秀芳，中国，202011469544.4

4. 一种可供注射的海参皂苷介孔二氧化硅纳米复合物及其制备方法和应用，李红燕，解万翠，杨锡洪，董秀芳，车红霞，宋琳，中国，202011625912.X

5. 一种包载海参皂苷的自组装纳米体系及其制备方法和应用，李红燕，解万翠，杨锡洪，车红霞，董秀芳，宋琳，中国，202011622525.0

6. 一种丹皮线性α-D-1,4-葡聚糖及其制备方法和应用，李红燕，解万翠，杨锡洪，董秀芳，车红霞，宋琳，中国，202110883581.8

7. 一种虾青素-壳聚糖自组装纳米复合物及其制备方法和应用，李红燕，解万翠，杨锡洪，车红霞，董秀芳，宋琳，中国，202110955254.9

8. A hyaluronic acid-astaxanthin self-assembled nano system and the preparation method and its application，李红燕，解万翠，杨锡洪，车红霞，董秀芳，国际专利

9. Extraction and preparation of the acidic polysaccharide extracted from Kaempfeia galangal L and its application in antibacterial preservation，李红燕，解万翠，杨锡洪，董秀芳，车红霞，国际专利

教学情况及获奖：

1.  主讲本科生课程：《海洋药物》、《有机波谱分析》

2.  2020年度山东省食品科学技术学会科学技术奖叁等奖，6/10

3.  指导国家级大学生创新创业训练计划项目，2020/06-2021/05