个人简介（包括近期科研项目）

车红霞，中国海洋大学食品科学与工程博士。2018年09月加入青岛科技大学海洋科学与生物工程学院，主要从事活性物质提取纯化、营养功效评价及构效关系研究。主持山东省青年基金、青岛科技大学高层次人才启动经费、北京工商大学重点实验室开放课题，参与国家重点研发项目子课题等项目。在《Food Research International》、《Food and Function》、《Molecular Nutrition and Food Research》、《Journal of Agricultural and Food Chemistry》等国际学术期刊发表SCI论文20余篇，参编中文专著1部。

主要研究方向：

1.海洋活性物质提取纯化

2.活性物质营养功效评价及构效关系研究

3.活性物质稳态化体系建立

近期科研项目：

1. 山东省自然科学青年项目：DHA/EPA-虾青素酯的消化吸收特征及其与肠道菌群的相互作用关系（ZR2020QC236），2021.01-2023.12，主持，经费15万元，在研。

2. 北京工商大学食品风味化学重点实验室开放课题：传统虾酱中优势微生物赋香机制与产品风味响应（SPFW2019YB01），2019.07-2020.07，主持，经费5万元，已结题。

3 青岛科技大学高层次人才启动基金，主持，经费20万元，在研。

近年发表的论文：

1. Jingwen Xie, Lin Liu, Hongyan Li, Hongxia Che*, Wancui Xie*. Ink melanin from Sepiapharaonis ameliorates colitis in mice via reducing oxidative stress, and protecting the intestinal mucosal barrier. Food Research International, 2022, 151.

2. Hongxia Che, Lingyu Zhang, Lin Ding, Wancui Xie, Xiaoming Jiang, Changhu Xue, Tiantian Zhang*, Yuming Wang*. EPA-Enriched Ethanolamine Plasmalogen and EPA-Enriched phosphatidylethanolamine Enhance BDNF/TrkB/CREB Signaling and inhibit Neuronal Apoptosis in Vitro and in Vivo. Food and Function, 2020, 11(2):1729-1739.

3. Hongxia Che, Hongyan Li, Lin Song, Xiufang Dong, Xihong Yang, Tiantian Zhang, Yuming Wang*, Wancui Xie*. Orally administered DHA enriched phospholipids and DHA enriched triglyceride relief oxidative stress, improve intestinal barrier, modulate inflammatory cytokine and gut microbiota, and meliorate inflammatory responses in the brain in DSS-induced colitis in mice. Molecular Nutrition and Food Research, 2021, 65(15), 2000986

4. Hongxia Che, Jing Yu, Jinyuan Sun, Kuan Lu, Wancui Xie*. Bacterial composition changes and volatile compounds during the fermentation of shrimp paste: Dynamic changes of microbial communities and flavor composition. Food Bioscience, 2021, 43.

5. LI Ye, YU Jie, XU Jie, CHE Hongxia *, WANG Yuming, XUE Changhu, HUANG Qingrong, ZHANG Tiantian *, Comparison of the Digestion and Absorption Characteristics of Docosahexaenoic Acid-Acylated Astaxanthin Monoester and Diester in Mice. Journal of Ocean University of China, 2021, 20, 973-984.

6. Zhu YF, Zhang TT, Ding L, Shi HH, Xue CH, Xie WC, Che, HX*, Wang, YM *, A Comparative Study About the Neuroprotective Effects of EPA-Enriched Phosphoethanolamine Plasmalogen and  Phosphatidylethanolamine Against Oxidative Damage in Primary Hippocampal Neurons. Journal of Ocean University of China, 2021, 20, 1207-1214.

7. Hongxia Che, Miaomiao Zhou, Tiantian Zhang, Lingyu Zhang, Lin Ding, Teruyoshi Yanagita, Jie Xu, Changhu Xue*, Yuming Wang*. Comparative study of the effects of phosphatidylcholine rich in DHA and EPA on Alzheimer’s disease and the possible mechanisms in CHO-APP/PS1 cells and SAMP8 mice. Food and Function, 2018, 9:643-654.

8. Hongxia Che, Miaomiao Zhou, Tiantian Zhang, Lingyu Zhang, Lin Ding, Teruyoshi Yanagita, Jie Xu, Changhu Xue*, Yuming Wang*. EPA enriched ethanolamine plasmalogens significantly improve cognition of Alzheimer’s disease mouse model by suppressingβ-amyloid generation. Journal of functional foods, 2018, 41:9-18.

9. Hongxia Che, Qian Li, Tiantian Zhang, Lin Ding, Lingyu Zhang, Haohao Shi, Teruyoshi Yanagita, Changhu Xue, Yaoguang Chang*, Yuming Wang*. A comparative study of EPA-enriched ethanolamine plasmalogen and EPA-enriched phosphatidylethanolamine on Aβ42induced cognitive deficiency in a rat model of Alzheimer’s disease. Food Function, 2018, 9:3008-3017.

10. Hongxia Che, Qian Li, Tiantian Zhang, Dandan Wang, Lu Yang, Jie Xu, Teruyoshi Yanagita, Changhu Xue, Yaoguang Chang*, Yuming Wang*. Effects of Astaxanthin and Docosahexaenoic-Acid-Acylated Astaxanthin on Alzheimer’s Disease in APP/PS1 Double-Transgenic Mice. Journal of Agricultural and Food Chemistry, 2018, 66: 4948-4957.

11. Hongxia Che, Xueyuan Fu, Lingyu Zhang, Xiang Gao, Min Wen, Lei Du, Changhu Xue, Jie Xu*, Yuming Wang*. Neuroprotective Effects of n-3 Polyunsaturated Fatty Acid-Enriched Phosphatidylserine Against Oxidative Damage in PC12 Cells, Cellular and Molecular Neurobiology, 2018,38(3):657-668.

12. Hongxia Che, Lei Du, Peixu Cong, Suyuan Tao, Ning Ding, Fengjuan Wu, Changhu Xue, Jie Xu*, Yuming Wang*. Cerebrosides from Sea Cucumber Protect Against Oxidative Stress in SAMP8 Mice and PC12 Cells, Journal of Medicinal Food, 2017, 20(4):392–402.

教学情况及获奖：

1. 主讲本科生课程：《食品化学》、《食品机械与设备》、《食品感官检验》。

2. 指导第十一届山东省大学生科技节，荣获研究生组一等奖